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High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks

In brief: Using structure-guided design, the authors develop second-generation ChroME-based cation channel rhodopsins that exhibit extremely high potency while preserving fast kinetics, thereby expanding the optogenetic toolbox. ChroME2.0 opsins permit spatially and temporally precise two-photon holographic neural control at unprecedented scales, a key technological step forward for understanding brain circuits and behavior.

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