Fiber-Based Optical Manipulation Application Note Overview: Fiber optic communications have long been of interest, but more recently the technology is being coupled with SLMs for imaging deep in tissue where scattering would otherwise prevent optical techniques from being practical. Much research is focused on imaging through multi-mode fibers due to the small form factor that […]
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Optogenetics Application Note Overview: Despite extensive research, brain function and neurological diseases are poorly understood. Complexities arise from the quantity of neurons in the brain and from the densely interconnected networks of intermixed cell types. There is a need for methods that non-invasively probe the underlying micro-circuitry in the brain with single-cell resolution…. [dflip id=”7039″][/dflip]
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Volumetric Imaging Application Note Overview: In order to understand biological functions at a system level it is necessary to imageinterconnectivity of processes in real time. This is particularly relevant in neuroscience, where the BRAIN initiative is funding research to understand how the brain functions, and how that function is altered by disease. This requires imaging
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Imaging In Scattering Or Turbid Media Overview: Adaptive optics was first utilized to correct for aberrations that are introduced when imaging through atmospheric turbulence. In monochromatic imaging systems or laser communication systems wavefront correction is most easily accomplished by adding a liquid crystal spatial light modulator to the imaging system. By applying an equal and
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Sensorless Adaptive Optics for Multimode Optical Fibre Endo-Microscopy Abstract: We demonstrate focus optimisation through multimode optical fibre usingsensorless adaptive optics. The optimisation can correct for the three-dimensional shift occurring when re-positioning the fibre into the system for chronic brain imaging. [dflip id=”7033″][/dflip] Use the three dots (…) below the page flip to download this resource.
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An open source three-mirror laser scanning holographic two-photon lithography system. Use the three dots (…) below the page flip to download this resource. [dflip id=”7031″][/dflip] request a quote or get technical questions answered
An open source three-mirror laser scanning holographic two-photon lithography system. Read More »
Revealing architectural order with quantitative label-free imaging and deep learning Abstract: We report quantitative label-free imaging with phase and polarization (QLIPP) for simultaneous measurement of density, anisotropy, and orientation of structures in unlabeled live cells and tissue slices. We combine QLIPP with deep neural networks to predict fluorescence images of diverse cell and tissue structures.
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Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing Use the three dots (…) below the page flip to download this resource. [dflip id=”7023″][/dflip] request a quote or get technical questions answered
The logic of recurrent circuits in the primary visual cortex Use the three dots (…) below the page flip to download this resource. [dflip id=”7019″][/dflip] request a quote or get technical questions answered
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High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks In brief: Using structure-guided design, the authors develop second-generation ChroME-based cation channel rhodopsins that exhibit extremely high potency while preserving fast kinetics, thereby expanding the optogenetic toolbox. ChroME2.0 opsins permit spatially and temporally precise two-photon holographic neural control at unprecedented scales, a
